For example NAHR between two copies of the CMT1A-REP segmental duplication on 17p12 leads to deletion of a 1.4 Mb region including the PMP22 gene resulting in hereditary neuropathy with liability to pressure palsies (HNPP), with reciprocal duplication of the same region resulting in Charcot-Marie-Tooth disease type 1A (CMT1A) [8]. Here, PMP22 is linked to Charcot-Marie-Tooth disease type 1A.