In the following we will summarize the data obtained in the previous years demonstrating the pivotal role of Bcl-2 proteins in hematologic compartment homeostasis (Figure 2), which may account for the observed association of hematologic malignancies with imbalanced Bcl-2 expression (Figure 1) and the marked susceptibility of hematologic malignancies toward Bcl-2-targeting strategies (Figure 3 and Table 1). The gene discussed is BCL2; the disease is hematologic disorder.