As a first approach using cellular vaccine vectors against listeriosis, we prepared different BMDM and DC vaccine vectors containing LM-WT, LLO, or GAPDH, and used them in vaccination protocols against an L. monocytogenes challenge of 5 × 103 bacteria/mice (n = 5), inoculated for 3 days. The gene discussed is GAPDH; the disease is listeriosis.