We have shown that AAA can be obtained in several ways either by inducing MHC class II expression in tumor cells by transfection with the AIR-1 gene-encoded MHC CIITA, thus providing functionally sufficient MHC-II–tumor peptide complexes for TH cell scrutiny, or by increasing the availability of tumor antigens by specific treatment of established tumors with L19mTNFα. The gene discussed is HLA-C; the disease is neoplasm.