CD274 and neoplasm: For instance, because the expression of PD-1 on T cells and PD-L1 on APCs facilitated increased Tregs and decreased CTL functions, PD-1/PD-L1 blockade with anti-PD-L1 monoclonal antibody decreased the infiltrating number of Tregs and increased the number and function of tumor reacting CTLs in an AML mouse model (167).