On the other hand, enhanced IL-6 responses accounted for the enhanced susceptibility of Socs3fl/flvav cre or Socs3fl/flLysM cre (deficient in SOCS3 in myeloid cells) mice to induced inflammatory diseases like rheumatoid arthritis (RA) or experimental autoimmune encephalomyelitis (EAE) (90, 98). Here, SOCS3 is linked to rheumatoid arthritis.