STAT3 and cancer: On the other hand, several inhibitors of STAT3, modulating either upstream positive or negative regulators, regulating RNA (DN-STAT3, anti-sense RNA, siRNA) and micro RNA, or small molecules targeting STAT3 at different domains have been approached (164, 165) principally to target constitutive STAT3 activation, which is associated with various human cancers and commonly suggests poor prognosis (166), although attempts to use it in infections or inflammation have not been done.