Ang (1–7) counteracts the pressor effects of Ang II as well as the proliferative and profibrotic effects of the peptide (65, 69, 70, 99, 100, 107, 108), reduces the incidence of heart failure after myocardial infarction in rats (99) and humans (109), and enhances the cardiac function, coronary perfusion, and aortic endothelial function (99). The gene discussed is AGT; the disease is heart failure.