There is a growing list of endogenous molecules involved in the regulation of adult neurogenesis, such as bFGF (basic Fibroblast Growth Factor), which promotes cortical cell replacement and functional recovery in neonatal (145) and adult (142) rats; EGF (Epidermal Growth Factor), a more potent augmenter of SVZ-derived cells in striatal tissue (146); and Nogo-A, a neurite inhibitor influential in murine models of ischemia and whose signaling cascade wields critical input in the regulation, maturation, and migration of NSCs from the SVZ (147, 148). Here, FGF2 is linked to ischemia.