The authors suggest to “include patients with CFTR variants presenting with risk factors in a screening and surveillance program and to strongly advise them not to smoke.” Three of the four cancer patients with CFTR mutation carried the p.L997F mutation (2× compound heterozygous, 1× heterozygous) which also had been identified at high frequency in patients with recurrent idiopathic pancreatitis (Gomez Lira et al., 2000). This evidence concerns the gene CFTR and cancer.