Panx1 and Panx3 expression is lower in keratinocyte-derived basal cell carcinoma and squamous cell carcinoma (Cowan et al., 2012), and a correlation has been reported between the aggressiveness of three isogenic metastatic melanoma cell lines and the level of Panx1 expression (Penuela et al., 2012). The gene discussed is PANX1; the disease is metastatic melanoma.