Panx1 and Panx3 expression is lower in keratinocyte-derived basal cell carcinoma and squamous cell carcinoma (Cowan et al., 2012), and a correlation has been reported between the aggressiveness of three isogenic metastatic melanoma cell lines and the level of Panx1 expression (Penuela et al., 2012). Here, PANX1 is linked to squamous cell carcinoma.