The first indication that Panxs might be involved in a specific pathology was observed in acute brain slices, when Roger Thompson and colleagues proposed that the massive disruption in electrochemical gradient which occurs across the plasma membrane of hippocampal neurons challenged with ischemia (i.e., oxygen/glucose deprivation, such as occurs during stroke) could be the result of Panx1 channel activity (Thompson et al., 2006). This evidence concerns the gene PANX1 and stroke disorder.