Co-localization of Panx2 and the mannose-6-phosphate receptor suggests that the endolysosome may be at least one intracellular target (Wicki-Stordeur et al., 2013), although no overlap was observed between exogenous GFP tagged Panx2 and LysoTracker® or EEA1 in C6 glioma cells (Lai et al., 2009). The gene discussed is PANX2; the disease is central nervous system cancer.