DYSF and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: Most recently, evidence points to an age-dependent enhancement in oxidative stress in dysferlin-deficient muscle (Prosser et al., 2013; Terrill et al., 2013) leading us to speculate that a progressive enhancement in oxidative stress may temporally associate with the late onset of muscle pathology seen in dysferlinopathy.