We reported that aged (~12 month) dysferlin-deficient murine muscle also exhibits amplified X-ROS signaling (Prosser et al., 2013), a finding congruent with the recent reports suggesting that oxidative stress underscores the late onset and temporal progression of dysferlinopathy (Terrill et al., 2013). This evidence concerns the gene DYSF and neuromuscular disease caused by qualitative or quantitative defects of dysferlin.