Another report shows that angiogenesis is impaired in mdx mice, not only in muscle, but systemically, which was proven by laser Doppler perfusion imaging in the hind limb ischemic model, VEGF induced neovascularization quantification in the corneal model, Matrigel subcutaneous angiogenic assay, and quantification of tumor growth and vascularization in the tumor implant model (Palladino et al., 2013). Here, VEGFA is linked to neoplasm.