Similarly, antagonizing the enzyme cyclo-oxygenase 2 (COX-2), responsible for the production of prostaglandins from arachidonic acid, reduces the sympathetic response to stimulation of the mechanoreflex to a larger degree in heart failure rats and patients than in healthy controls (Middlekauff et al., 2008; Morales et al., 2012). This evidence concerns the gene PTGS2 and heart failure.