mtCaMKIIN (with mitochondrial localization sequence) and palmitoyl-CaMKIIN for membrane localization support a role of mitochondrial CaMKII in ischemia reperfusion injury, MI and neurohumoral injury due to increased inner membrane mitochondrial Ca2+ uniporter current (Joiner etal., 2012). The gene discussed is CAMK2G; the disease is ischemia.