Since SAP97 and CaMKII have been shown to interact (El-Haou et al., 2009), CaMKII expression is increased in AF (Tessier et al., 1999; Neef et al., 2010), and given the similarities between SAP97-dependent Kv4.3 and Kv1.5 regulation (Tessier et al., 1999; Godreau et al., 2002; El-Haou et al., 2009), it seems tempting to speculate that CaMKII could also regulate Kv1.5. The gene discussed is KCNA5; the disease is atrial fibrillation.