PINK1 and Parkinson disease: In fact, antisense-mediated inactivation of TIGAR induces a complete normalization of impaired mitochondrial metabolism (morphology, complex I and III activity) in pink-/- zebrafish with ensuing rescue of dopaminergic neurons, suggesting that the manipulation of its physiological level can be a promising novel target for disease-modifying therapy in PINK1-related PD (Flinn et al., 2013).