TNF-α blockage may induce autoimmune phenomena in individuals with some genetic background as confirmed by the onset of autoantibodies (50% of antinuclear antibodies and 15% of anti-DNA antibodies), drug induced lupus, vasculitis, antiphospholipid syndrome, and other autoimmune entities [21, 49, 50, 60, 61]. The gene discussed is TNF; the disease is systemic lupus erythematosus.