A recent study in dorsal root ganglia found ANO1 to be in a complex with the inositol 1,4,5-trisphosphate receptor 1, bradykinin receptor 2, the protease-activated receptor 2, and caveolin and to be tethered to juxtamembrane regions of the ER and suggests that a similar complex may exist in cancer cells (43). This evidence concerns the gene F2RL1 and cancer.