This variant is also located near the major histocompatibility complex (MHC or human leukocyte antigen, HLA) region in chromosome 6 (6p21.33), as is the GWAS variant for FL (rs6457327), and has been associated with the risk of systemic lupus erythematosus in a GWAS [41]. The gene discussed is HLA-C; the disease is systemic lupus erythematosus.