NANOGP8 and cancer: Our recent studies demonstrate that inducible NanogP8 expression in bulk PCa cells is sufficient to confer cancer stem cell (CSC) properties and promote androgen-independent PCa growth [34] and that NanogP8 is enriched in undifferentiated (PSA-/lo) PCa cells and its knockdown retards outgrowth of castration-resistant PCa [41].