FKBP1B and heart failure: Protein kinase A phosphorylation of the cardiac RyR during myocardial infarction has been argued to lead to dissociation of FKBP12.6 (Wehrens et al., 2005 ▶), and drugs designed to prevent this dissociation have been proposed to inhibit heart failure progression in mice (Shan et al., 2010 ▶), although this approach remains controversial (Bers, 2012 ▶; Eschenhagen, 2010 ▶).