The transgenic MSA mouse models mostly depend on the overexpression of human α-Syn (hα-Syn) under the control of different oligodendroglial promoters (PLP (Kahle et al., 2002), MBP (Shults et al., 2005), CNP (Yazawa et al., 2005)) (see Table 1 for an overview of these transgenic models). This evidence concerns the gene CNP and multiple system atrophy.