Interestingly, wild-type p53 expression was detected in 47% of colorectal adenocarcinomas [46], and approximately 70–80% of mesothelioma cells, although having the wild-type p53 gene, show a homologous deletion at the INK4A/ARF locus containing the p14ARF and the p16INK4A genes, which consequently leads to decreased p53 functions despite the wild-type genotype [47]. This evidence concerns the gene CDKN2A and colorectal adenocarcinoma.