Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K/Akt pathway and CF-induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer. This evidence concerns the gene CDKN1A and malignant colon neoplasm.