Taken together, these findings establish an interaction between p53, c-myc, Bcl-2, p21, p27 and PI3K/Akt pathway and CF-induced apoptosis in MSTO-211 and HCT-116 cells, which may improve prevention outcomes for mesothelioma and colon cancer. The gene discussed is CDKN1B; the disease is cystic fibrosis.