In this study, we demonstrated that RasG12V, which is the form of Ras that recapitulates the activation of Ras by multiple RTKs (as is the case in breast cancer), induced the release of CXCL8 and CCL2 from MCF-7 human breast tumor cells, without any need to cooperate with the down-regulation of p53. The gene discussed is CCL2; the disease is breast carcinoma.