CXCL8 and neoplasm: However, in contrast to the non-transformed cells [9], RasG12V was fully active on its own in inducing CXCL8 in the tumor cells, at the protein and mRNA levels (Figure 1A and B, respectively), while p53shRNA alone did not induce any change in chemokine expression, and did not add significantly to CXCL8 up-regulation by RasG12V (Figure 1A and B).