To comply with this limitation, and in line with our interest in determining the overall effects induced by multiple angiogenic factors that could have been promoted by the most potent process of TNFα stimulation of WT-Ras-expressing cells, we tested CM from the two most relevant stimulatory extreme conditions: (1) CM of WT-Ras-expressing tumor cells that were stimulated by TNFα. The gene discussed is TNF; the disease is neoplasm.