TNF and neoplasm: Therefore, these results indicate that in order to metastasize, the cells required the expression of RasG12V, but they also attest for the functional importance of the cooperativity between TNFα and Ras hyper-activation: Following joint activities of TNFα and Ras hyper-activation, the cells released high levels of tumor-promoting factors, which potentiated the metastatic potential of the tumor cells and their dissemination to LN.