Nodule aspirates positive for: galectin-3, BRAF point mutations, the formation of PAX8-PPARγ1 chimeric oncogene, and the RET/PTC mutation have all been associated (even if to different extents) with thyroid cancer risk [8,12,17,25-27]; thus, the combined analysis of multiple markers is likely to be of the greatest clinical use in reducing the rate of unnecessary surgical procedures and associated complications [8]. This evidence concerns the gene PAX8 and thyroid cancer.