It was also found that, in the pathological conditions associated with mitochondrial iron overload, such as Alzheimer’s disease, PD, and sideroblastic anemia, the FtMt expression was largely induced (Cazzola et al., 2003; Shi et al., 2010; Wang et al., 2011; Wu et al., 2013; Yang et al., 2013). The gene discussed is FTMT; the disease is early-onset autosomal dominant Alzheimer disease.