BCL6 and diffuse large B-cell lymphoma: Other mechanisms causing constitutive expression of BCL6 have been described; mutations disrupting a negative regulatory site in the promoter region of the BCL6 gene occur in 10 to 15% of DLBCL [21], [22] and disruption of normal post-translational regulation of BCL6 by various mechanisms have also been reported and are likely to contribute to deregulated expression [23]–[25].