These include the weak correlation between the fAβ and synaptic loss, neuronal death, or cognitive impairment [3], [4], [5], the strong correlation between sAβ levels and the severity of neuropathological changes in AD, as well as the potent ability of sAβ to cause synaptic failure and cognitive function disruption [6], [7]. This evidence concerns the gene SH3BP5 and Cognitive impairment.