LGALS1 and pancreatic neoplasm: In addition, we also found that the metastatic peripancreatic lymph nodes existed Galectin-1 positive straining, which have not well observed in other researches and might be explained as follows: first, the high Galectin-1 expressed in stromal cells, especially activated PSCs, induced epithelial-mesenchymal transition (EMT) in the pancreatic cancers cells[41]; second, the high level of Galectin-1 in PSCs promoted the cancer cells to acquire a metastatic phenotype[12], [42], accordingly the cancer cells itself increased the Galectin-1 expression and acquired an advanced progression.