Additionally, the levels of IGF-1 showed a trend toward a decrease with advancingtumor stage, determined by the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) staging (ρ = −0.218, P = 0.01) and Okuda (ρ = −0.273, P = 0.001). Here, IGF1 is linked to neoplasm.