Univariate Cox analyses showed thathigh Child-Pugh score, larger tumor size (≥5 cm), multiple tumors (i.e., >1), presence of portal vein thrombosis (PVT), advanced BCLC stage, increasing levels of VEGF, and decreasing levels of IGF-1 were significantly associated with shorter TTP (Table 2). This evidence concerns the gene IGF1 and Portal vein thrombosis.