HGF and neoplasm: The HGF-antagonist-designated NK4, consisting of the NH2-terminal hairpin domain and the four kringle domains of the HGF α-chain, binds to c-Met and competitively antagonizes HGF-induced tyrosine phosphorylation of c-Met, resulting in inhibition of HGF-mediated cell proliferation, migration, invasion, angiogenesis and lymphangiogenesis and in antiapoptotic effects that contribute to malignant growth of tumor cells [18].