The emergence of the PMQR and, above all, the emergence of concurrent transferable cephamycin, oxymino-cephalosporin, and beta-lactamase inhibitor resistance in multidrug-resistant Klebsiella isolates in pets, a recent issue even in human therapy [54], may pose in the next future further and serious therapeutic challenges also in bacterial infections of companion animals. The gene discussed is LACTB; the disease is bacterial infectious disease.