Moreover, KPT-185 also induced cell cycle arrest at the G1/S checkpoint in KPT-185-sensitive NSCLC cell lines, down-regulated levels of CRM1 and EGFR protein, accumulated p53, IκB-α and NF-κB in nucleus, and activated caspases-8, 3, and 9 proteins in NSCLC cells. The gene discussed is XPO1; the disease is non-small cell lung carcinoma.