XPO1 and mantle cell lymphoma: For example, Zhang showed that CRM1 siRNA led to CRM1 protein knockdown and reduced mantle cell lymphoma (MCL) cell viability, and SINEs induced CRM1 protein translocation into the nucleus, where its expression was down-regulated [22]; thus, these data appeared to be opposite to former CRM1 inhibitors [13], [14], [24], [25].