In the studied failing myocardium, the expression of ANKRD1 (ankyrin repeat domain 1 protein), the surrogate marker of HF [48], was significantly upregulated (Fig. 5 B, E), while the levels of TNNI3 (cardiac troponin I; the marker of acute myocardial ischemia) were unchanged or slightly augmented as compared to non-failing samples (see Fig. 5 B). The gene discussed is ANKRD1; the disease is hydrops fetalis.