In this paper we provide what are, to our knowledge, the first reported results, demonstrating: (1) the re-activation of Pitx2c expression in failing myocardium in different HF settings, (2) the marked upregulation of Myf5 myogenic factor expression in failing ventricular and atrial myocardium as well as in cultured cardiomyocytes in response to forced expression of Pitx2c, and (3) the expression of the large repertoire of myogenic regulatory factors (MRFs) in normal and failing myocardium. This evidence concerns the gene MYF5 and hydrops fetalis.