TARDBP and Pick disease: Furthermore, this variety of filamentous structures that can form from TDP-43 is not limited to FTLD-TDP as randomly oriented and bundled TDP-43 filaments have been reported for AD, Pick's disease and Lewy body disease cases as well, and immuno-gold labeling of these sections with phosphorylation-specific TDP-43 and ubiquitin antibodies confirms these filaments also may contain post-translationally modified TDP-43 [16], [21], [22].