In light of the caveats in those studies, the findings presented here that demonstrate CKII does promote the assembly of rTDP-43 into 9.9 nm wide filaments characterizing many TDP-43 proteinopathies suggests CKII phosphorylation of TDP-43 may be pathologically relevant and have therapeutic potential. The gene discussed is TARDBP; the disease is proteostasis deficiencies.