Furthermore the assembly of this soluble rTDP-43 into 9.9 +/− 0.9 nm diameter filaments that characterize the predominant 10–12 nm forms of filamentous TDP-43 inclusions observed in ALS, FTLD and AD provides the best resource to date for studying the effects of TDP-43 filament assembly on TDP-43 function and the ability of these filaments to sequester wild-type TDP-43 or other cellular components. Here, TARDBP is linked to amyotrophic lateral sclerosis.