CSNK2A1 and AL amyloidosis: Intriguingly, CKII phosphorylation of Cdc37 is thought to be essential for Cdc37/Hsp90 chaperoning function indicating CKII activation may stabilize the Cdc37/Hsp90 clients as observed in multiple myeloma, and hence these clients may additionally be targeted for degradation by the use of CKII inhibitors that block Cdc37 phosphorylation [52].