In the final multivariate analysis, the presence of CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2–0.6) or ≥200–350 cells/mm3 (OR 0.6; 95% CI 0.4–1.0) (Ref: <200 cells/mm3 CD4), parity ≥1 (OR: 2.5; 95% CI: 1.3–4.9) and being single (OR: 1.6; 95% CI: 1.1–2.4) whereas ART use was no longer associated (p = 0.26). Here, CD4 is linked to cervical squamous intraepithelial neoplasia.