In the present study, we investigated the association among sTWEAK and sCD163 plasma concentrations, the sCD163/sTWEAK ratio and other inflammatory, endothelial dysfunction and thrombotic biomarkers (hsCRP, IL-6, sTNFRII, sVCAM-1, ADMA and D-dimer) with the presence of HIV infection. This evidence concerns the gene IL6 and HIV infectious disease.