Studies using chemically-induced or natively occurring Bicc1-mutant mouse models (jcpk and bpk) and other Bicc1-gene-targeted mouse models have recently demonstrated that the disruption of Bicc1 can induce polycystic kidney disease with phenotypes very similar to human ADPKD [5], [6], [17]. The gene discussed is BICC1; the disease is polycystic kidney disease.