CXCL12 and neoplasm: Weekly tracking measurements of total radiance in the animals revealed a significant decrease in percent change of tumor burden throughout the course of the study (Fig.10B).Over time, mice with tumor cells producing CXCL12 had lower tumor burden when assessed at early, middle, and later time points as visualized by bioluminescent imaging at days 7, 49, and 98, respectively (Fig.10C–D).