We showed that re-expression of CXCL12 decreased the ability of breast and colorectal cancer cells to metastasize [24]–[26].Several studies haveextended those seminal findings to show beneficial effects of autocrine CXCL12 in breast, lung, gastric, and head and neck cancers [27]–[30]. This evidence concerns the gene CXCL12 and head and neck cancer.