The functions of CXCR4, CXCR7 or CXCL12 in pancreatic cancer progression remain based on limited analyses without simultaneous analysis of all three chemokine signaling components in both normal and diseased tissue.Immunostaining of serial tissue sectionswith specific antibodies,revealedrobust CXCL12 staining on normal ductal epithelial cells, with those same epitheliaalso staining positive for CXCR4 and CXCR7(Fig.1A &Fig. 2A). Here, ACKR3 is linked to familial pancreatic carcinoma.