Considering that evasion of apoptosis is one of the hallmarks of human cancers [9]and radiotherapy-induced cytotoxicity is mediated, to a large extent, by the induction of apoptosis in cancer cells [10], [11], we speculate that hPEBP4 may participate in the resistance of rectal cancer to preoperative radiotherapy. Here, PEBP4 is linked to rectal cancer.