We can even make a daring speculation that Src kinase may be the intermediate scaffold for the interaction between hPEBP4, ROS and Akt since we've provided the direct evidence of association between hPEBP4 and Src in another work with breast cancer cells and Src had been demonstrated to be required in the activation of Akt by ROS previously [32], [37]. Here, AKT1 is linked to breast cancer.