PEBP4 and rectal cancer: Actually in a recent work, we had demonstrated that hPEBP4 expression in a pretreatment biopsy specimen as an independent predictor of response to preoperative radiotherapy in patients with rectal cancer and we found a dramatic upregulation of hPEBP4 expression in rectal cancer tissues after preoperative radiotherapy comprared with the biopsy specimen during colonoscopy examination, suggesting that hPEBP4 might play a role in the radioresistance of rectal cancer, though a direct link between hPEBP4 and radioresistance was not provided at that time [12].