PTTG1 and pituitary gland adenoma: Although the exact function of PTTG in the development and progression of pituitary adenomas is not fully understood yet, a potential explanation might be that high expression of PTTG could cause cell transformation and induce aneuploidy with the abundance or absence of PTTG may lead to the dysregulation of G2/M checkpoint surveillance, leading to abnormal mitosis and chromosomal instability [58]–[60].