ADIPOQ and nonpapillary renal cell carcinoma: Our previous studies have also shown that adiponectin inhibits the angiogenic, invasive and migratory capacities in clear cell RCC (ccRCC) cells via adiponectin receptor 1 (AdipoR1) [7] and that these tumor-suppressive effects are diminished in RCC not only due to decreased plasma adiponectin levels [5], but also as a result of reduced AdipoR1 expression [7].