Since ERp46 has previously been suggested to act as a negative modulator of the adiponectin signal transduction pathway through binding to AdipoR1, but not AdipoR2 [11] and we found that AdipoR1 was the primary receptor through which adiponectin exerts its effects [7], we also determined the ratio of ERp46/AdipoR1 protein expression in specimens of ccRCC patients (Figure 1d) using the H-scores from the same TMA stained for AdipoR1 [7]. Here, ADIPOR2 is linked to nonpapillary renal cell carcinoma.