ADIPOR1 and nonpapillary renal cell carcinoma: Previous studies from our laboratory on ccRCC patients and ccRCC models in vitro and in vivo have shown that adiponectin has tumor-suppressive effects [7] and that this hormonal axis is inhibited in ccRCC secondary to hypoadiponectinemia [5] and underexpression of AdipoR1 in the tumor tissue [7].