Nevertheless, given that small-molecule inhibitor of TNKS1 and TNKS2 exerts anti-tumor effect through downregulating Wnt signaling by function as an Axin stabilizer [49], Poly-ADP-ribosylation -dependent ubiquitination of Axin provides an alternative and promising opportunity for targeting Wnt pathway for cancer therapy. The gene discussed is TNKS; the disease is cancer.