STRADA and polyhydramnios, megalencephaly, and symptomatic epilepsy: While little is known about STRADβ function, homozygous deletion within the human LYK5 (STRADα) locus (see Additional file 1: Figure S3A) results in a syndromic condition known as polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) [8].