A significant correlation between the expression of p-TSC2 and p-mTOR was found in AC specimens (p-TSC2 vs. nuclear p-mTOR: correlation coefficient (CC) = 0.305; p = 0.004; p-TSC2 vs. cytoplasmic p-mTOR: CC = 0.303; p = 0.016) and in SCLC specimens (p-TSC2 vs. nuclear p-mTOR: CC = 0.409; p = 0.006; pTSC2 vs. cytoplasmic p-mTOR: CC = 0.422; p = 0.005). Here, TSC2 is linked to small cell lung carcinoma.