Both IL-8 and CXCR2 expression increased along with Fuhrman’s grade and stage advocating that IL-8/CXCR2 autocrine signaling underpins both the development and the progression of RCC and represents a mechanism adopted by diverse tumor types to augment their angiogenic, growth and metastatic potential [32]. The gene discussed is CXCL8; the disease is neoplasm.