LGALS3 and melanoma: Another study has shown that lysosomal-associated membrane protein-1 (LAMP-1) on highly metastatic melanoma cells carries N-acetyllactosaminyl structures, which are recognized by Galectin-3 on lung endothelial cells suggesting that lung endothelial galectin-3 can serve as anchor for LAMP-1 expressing tumor cells in the circulation (141).