The second locus, on chromosome 18p11.31, was reported by Al-Sukhni as a duplication event in a single case and harbors four known genes including ARHGAP28, LINC00668, LAMA1, LRRC30. Notably, LAMA1 (laminin subunit alpha-1 precursor) encodes a subunit of the extracellular protein laminin. While the specific role of laminin in pancreatic tumorgenesis remains poorly understood, a recent study by Vincent et al. found that LAMA1 was among several genes that were hypermethylated and underexpressed in pancreatic tumor samples compared to normal pancreas (Vincent et al., 2011). Here, ARHGAP28 is linked to pancreatic neoplasm.