LAMB2 and pancreatic neoplasm: The second locus, on chromosome 18p11.31, was reported by Al-Sukhni as a duplication event in a single case and harbors four known genes including ARHGAP28, LINC00668, LAMA1, LRRC30. Notably, LAMA1 (laminin subunit alpha-1 precursor) encodes a subunit of the extracellular protein laminin. While the specific role of laminin in pancreatic tumorgenesis remains poorly understood, a recent study by Vincent et al. found that LAMA1 was among several genes that were hypermethylated and underexpressed in pancreatic tumor samples compared to normal pancreas (Vincent et al., 2011).