GSTM1 and Schnyder corneal dystrophy: Unsupervised analysis identified similar clustering by Hb genotype, SCD SV and the clinical status effect (Figures 1A,B), with Hb genotype and the clinical status effect explaining 45.2 and 6.9% of the variance of the first three ePCs in the replication phase, respectively (Figure 1C, Figure S4).