CIMAP3 and Schnyder corneal dystrophy: We identified 11 eSNP interaction effects that are dependent on clinical status for this class of genes, six of which remained genome-wide significant after accounting for relatedness in the entire sample using a Q-K mixed model: ZSCAN12L1, C9ORF173, CAPZA1, SVIL, MEF2A, and C1ORF88. These genes represent novel SCD associations, form an interacting network generated using Ingenuity Pathway Analysis (www.ingenuity.com) (Figure S8) and have some overlapping clinical manifestations, particularly with respect to cardiovascular disease.