For example, the muscle protein tropomyosin (AllFam code AF054) is an important IgE target in a number of nematode infections; Onchocerca volvulus (76, 77); Ascaris lumbricoides (78); Anisakis simplex [Ani s 3, (46)]; and tropomyosin from the blood fluke Schistosoma mansoni is also a human IgE antigen (Fitzsimmons, unpublished data). The gene discussed is IGHE; the disease is Nematoda infectious disease.