IGHE and infection: While some of the Top 10 allergen families (tropomyosins, EF-hand proteins, PR-1, and lipocalins) have members in helminth species that are known to be targeted by IgE during infection, other common allergen families (profilin, trypsin-like serine proteases, and lipocalin) have been identified in helminths, but their IgE binding has not yet been tested (96).